Keywords: chronic leukemia

    Chronic leukemia, divided into chronic myeloid leukemia and chronic lymphocytic leukemia. . Chronic myelogenous leukemia, or CML (chronic myelognous leukemia, CML) is an onset and relatively slow development of clinical leukemia. He is a originated in the bone marrow pluripotent hematopoietic stem cells of malignant proliferative diseases, the performance for the myeloid progenitor cell pool expansion and myeloid cell lines and their progenitor cell overgrowth. More than 90% of cases of CML marker chromosomes – ph1 chromosome molecular basis of the ber / abl gene rearrangement. CML clinical fatigue, weight loss, fever, splenomegaly, and leukocyte abnormally high levels as the main performance. The CML incidence in the world are not consistent. CML incidence findings of the annual incidence of 036/100 000, 20% of CML in our accounting for various types of leukemia, accounting for 95% of chronic leukemia. The age of onset is widely distributed, but the gradual upward trend in the growth of the incidence of age. Males more than females. Chronic lymphocytic leukemia, referred to as CLL (chronic lymphocytic leukemia, CLL), the body’s abnormal proliferation of lymphocytes in the body and savings associated with immune dysfunction disease. In our the CLL incidence of low, generally accounts for only 10% of the total number of leukemia incidence, ranking leukemia type 4. CLL lymphocytes in patients with extremely long life, and is often associated with defects of the immune response, it is also known as “the immune incompetence lymphocytes accumulation disease.
    The main clinical manifestations in lymph nodes based, often accompanied by hepatosplenomegaly, anemia and bleeding and other symptoms associated with skin lesions in a few patients. The disease mostly elderly occasionally young men than women.
    Clinical lymph node enlargement, hepatosplenomegaly and fatigue characteristics of chronic leukemia, is a traditional Chinese medicine, “Zhengjia" accumulation “, M. scrofulaceum," Consumption “and other areas.

    】 【Cause
    1, Chinese medicine
    The ① impassioned internal injuries, emotional tone, caused by poor qi, liver qi stagnation, qi course of time, the blood stasis, context stop up together, stop bleeding, into blocks Hisatsumi.
    ② eating disorders, too Feigan Gastropub hurt the stomach, spleen loss of transportation, transmission and the cloth body fluid has no right, dampness, endogenous, condensed into a plot, sputum gas Competing poor blood flow, stasis block endogenous.
    ③ onwards into impermanence, cold temperature is not adjusted, the feelings of evils.
    2, Western medicine
    (A) The pathogenesis of chronic myeloid leukemia
    (1) cytogenetic
    (2) G-6-PD isoenzyme
    (3) Cellular Dynamics
    (4) spleen factors spleen the role played in the pathogenesis of CML, many experimental and clinical observations indicate that spleen conducive leukemia cell migration, proliferation, and blastic phase. State is different myeloid proliferation in the spleen, the spleen is not only “capture" the leukemia cells, but also the leukemia cells warehouse “and" shelter “and its proliferation transfer provides a favorable environment, and leukemia cells in the bone marrow and from cycle to increase between the blood and the spleen cells release a normal adjustment process damage.
    (B) The pathogenesis of chronic lymphocytic leukemia.
    (1) chromosomal abnormalities
    (2) Cloning of the leukemia occurred
    (3) abnormal cell kinetics
    
    [Typing]
    Chronic leukemia, divided into chronic myeloid leukemia and chronic lymphocytic leukemia.

    Clinical manifestations
    Clinical manifestations: patients mostly the elderly, the very slow onset, often have no symptoms, even confirmed by laboratory tests.
    (1) symptoms: early can be a languid, gradually dizziness, palpitations, shortness of breath, weight loss, fever, night sweats, skin purpura, pruritus, bone pain, often prone to infection, approximately 10% of patients may be complicated by autoimmune hemolytic anemia.
    (2) signs: (1) swollen lymph nodes, swollen lymph nodes in the neck the most common, followed by axillary lymph nodes, groin and tackle generally showed moderate hardness, smooth surface, no tenderness, epidermal swelling, no adhesion. Mediastinal lymph nodes, bronchial compression caused by coughing, hoarseness or breathing difficulties. CT scans can be found in the retroperitoneal, and mesenteric lymph nodes. ② hepatosplenomegaly: mild swelling of the liver, splenomegaly, accounting for about 72% of the general ribs 3 ~ 4crn, individual patients can flat umbilical enlargement was chronic myeloid leukemia degrees less than obvious. (3) skin lesions: skin thickening, nodules, resulting in generalized erythroderma.
    2, laboratory tests
    (1) blood: the total number of white blood cells often> 15 × 109 / L, and the general classification of 30 × 109 / L ~ 200 × 109 / L, about 80% to 90% for mature small lymphocytes, a small amount of atypical lymphocytes and immature lymphocytes, blood-chip is easy to see broken cells, reduced hemoglobin and platelet count with the progression of the disease. The anemia is positive cells are pigmented anemia, hemolytic reticulocytes increased.
    (2) bone marrow: active, marked hyperplasia of lymphoid dominant mature small lymphocytes accounted for 50% to 90%, occasionally raw and immature lymphocytes, late shows red tablets, giant cells significantly reduced. Hemolysis, erythroid cells visible compensatory hyperplasia.
    (3) immunological tests: cell surface markers with monoclonal immunological characteristics of cell chronic lymphocytic leukemia (the Sig, CD5, C3d can, CD19, CD20, CD4, the mouse erythrocyte rose petals receptor positive), individual patients blood visible monoclonal immunoglobulin. Hemolytic visible anti-human globulin test positive. (4) cytogenetic: about half of the chronic lymphocytic leukemia chromosomal abnormalities, the most common abnormal number is increased by one on the 12th chromosome (+12), followed by visible number No. 3, No. 16, or chromosome 18. Common structural abnormalities 12 and on the 11th chromosome reciprocal translocation, the deletion of the short arm or the long arm of chromosome 6, the long arm of chromosome 11 deletion, chromosomal changes increase the long arm of chromosome 14. Reported, chronic lymphocytic leukemia patients with “+12″ period indications for treatment of clinical symptoms was significantly shorter than the control group without the “+12″, from diagnosis to occur, so that the “+12″ seems a short course of the disease and adverse prognosis.
    (5) Biochemical and staining: lymphocytes strongly positive PAS reaction, approximately 1/3 of the patients Coomb’s test positive. Some patients have hypogammaglobulinemia hyperlipidemia, plant hemagglutinin (PHA) conversion rate is significantly reduced.
    3. CML: chronic lymphocytic chronic lymphocytic acute change rare occurrence of dramatic changes in the time range of 1 to 20 years. Can occur with acute lymphoblastic leukemia, acute myeloid leukemia, acute monocytic leukemia, stem cell leukemia, acute plasma cell leukemia and erythroleukemia. The event of rapid change, often rapidly fatal.

    【Diagnostic criteria is not sick, we must conduct clinical diagnosis: http://www.hope.net.cn / clinical / index.html to be responsible for the lives.
    Western medicine diagnosis and differential assertion 〖diagnosis〗
    Clinical manifestations: patients mostly the elderly, the very slow onset, often have no symptoms, even confirmed by laboratory tests.
    (1) symptoms: early can be a languid, gradually dizziness, palpitations, shortness of breath, weight loss, fever, night sweats, skin purpura, pruritus, bone pain, often prone to infection, approximately 10% of patients may be complicated by autoimmune hemolytic anemia.
    (2) signs:
    (1) swollen lymph nodes, swollen lymph nodes in the neck is the most common, followed by swollen lymph nodes in the armpits, groin and tackle generally showed moderate hardness, smooth surface, no tenderness, epidermal swelling, no adhesion. Mediastinal lymph nodes, bronchial compression caused by coughing, hoarseness or breathing difficulties. CT scans can be found in the retroperitoneal, and mesenteric lymph nodes.
    ② hepatosplenomegaly: mild swelling of the liver, splenomegaly, accounting for about 72% of the general ribs 3 ~ 4crn, individual patients can flat umbilical enlargement was chronic myeloid leukemia degrees less than obvious.
    (3) skin lesions: skin thickening, nodules, resulting in generalized erythroderma.
    2, laboratory tests
    (1) blood: the total number of white blood cells often> 15 × 109 / L, and the general classification of 30 × 109 / L ~ 200 × 109 / L, about 80% to 90% for mature small lymphocytes, a small amount of atypical lymphocytes and immature lymphocytes, blood-chip is easy to see broken cells, reduced hemoglobin and platelet count with the progression of the disease. The anemia is positive cells are pigmented anemia, hemolytic reticulocytes increased.
    (2) bone marrow: active, marked hyperplasia of lymphoid dominant mature small lymphocytes accounted for 50% to 90%, occasionally raw and immature lymphocytes, late shows red tablets, giant cells significantly reduced. Hemolysis, erythroid cells visible compensatory hyperplasia.
    (3) immunological tests: cell surface markers with monoclonal immunological characteristics of cell chronic lymphocytic leukemia (the Sig, CD5, C3d can, CD19, CD20, CD4, the mouse erythrocyte rose petals receptor positive), individual patients blood visible monoclonal immunoglobulin. Hemolytic visible anti-human globulin test positive.
    (4) cytogenetic: about half of the chronic lymphocytic leukemia chromosomal abnormalities, the most common abnormal number is increased by one on the 12th chromosome (+12), followed by visible number No. 3, No. 16, or chromosome 18. Common structural abnormalities 12 and on the 11th chromosome reciprocal translocation, the deletion of the short arm or the long arm of chromosome 6, the long arm of chromosome 11 deletion, chromosomal changes increase the long arm of chromosome 14. Reported, chronic lymphocytic leukemia patients with “+12″ period indications for treatment of clinical symptoms was significantly shorter than the control group without the “+12″, from diagnosis to occur, so that the “+12″ seems a short course of the disease and adverse prognosis.
    (5) Biochemical and staining: lymphocytes strongly positive PAS reaction, approximately 1/3 of the patients Coomb’s test positive. Some patients have hypogammaglobulinemia hyperlipidemia, plant hemagglutinin (PHA) conversion rate is significantly reduced. .
    , Chronic lymphocytic blast crisis: acute chronic lymphocytic becomes rare occurrence of dramatic changes in the time range of 1 to 20 years. Can occur with acute lymphoblastic leukemia, acute myeloid leukemia, acute monocytic leukemia, stem cell leukemia, acute plasma cell leukemia and erythroleukemia. The event of rapid change, often rapidly fatal.
    4, the diagnostic criteria
    (1) Clinical manifestations:
    ① may have fatigue, physical decline, weight loss, fever, anemia or hemorrhagic manifestations.
    (2) may have lymph nodes (including head and neck, armpits, groin), liver and spleen.
    (2) laboratory tests:
    ① peripheral blood WBC> 10 x 109 / L, and the proportion of lymphocytes ≥ 50% of the absolute value of ≥ 5 × 109 / L, form of mature lymphocytes, immature lymphocytes or atypical lymphocytes.
    ② bone marrow like: myeloproliferative active or was active, lymphocytes ≥ 40% mature lymphocytes.
    (3) immunophenotyping:
    ① B-CLL: the mouse rosette test positive the: SIg weakly positive, was the K or λ monoclonal light chain; CD5, CD19, CD20-positive; CD10, CD22 negative.
    ② T-CLL: the sheep rosette test positive: CD2, CD3, CD8 (or CD4) positive, CD5 negative.
    (4) morphological classification: B-CLL is divided into three subtypes:
    ① typical of CLL: more than 90% of for similar mature small lymphocytes.
    ② CLL with prolymphocytic increased (CLL / PL): naive lymphocytes> 10% but <50%.
    (3) mixed cell type: the different proportions of the atypical lymphocytes, cell volume, reduced the proportion of nuclear / cytoplasm, basophilic staining cytoplasm to varying degrees, with or without the azurophilic granules.
    T-CLL cell morphology is divided into the following four kinds:
    ① large lymphocyte type: larger cell, the cytoplasm is light blue, with fine or coarse azurophilic granules, the nucleus round or oval, often to one side, staining quality poly Manifold, nuclear Ren rare.
    ② naive T-cell type: enhanced nucleus basophilic, particles, prominent nucleoli.
    ③ was small or large lymphocytes gyri-like nucleus.
    ④ morphological diversity, the nucleus multi partakers leaves.
    (5) clinical staging criteria:
    ① I period: lymphocytosis, and may be accompanied by swollen lymph nodes.
    ② Ⅱ period: Ⅰ of liver plus or splenomegaly, thrombocytopenia <100 x 109 / L.
    ③ Ⅲ: Ⅰ period plus or Phase Ⅱ anemia (Hb <100 g / L).
    Except lymphoma with leukemia and juvenile lymphocytic leukemia, sustained increases in peripheral blood lymphocytes ≥ 3 months, and may exclude viral infections, tuberculosis, typhoid fever, an increase in infectious mononucleosis psychosis caused lymphocytosis disease should be suspected this disease. In the longer-term continuous observation, lymphocytes still no decline, combined with clinical, blood, bone marrow and immune phenotype-based disease can be diagnosed.
    ー differential diagnosis-
    Lymph nodes, leukocytosis and hepatosplenomegaly characteristics, clinical need with the following diseases.
    (1) chronic myeloid leukemia: white blood cells increased significantly (100 × 109 ~ 500 × 109 / L), bone marrow, mainly in late promyelocytic hyperplasia, neutrophil alkaline phosphatase decreased or disappeared, Ph ‘chromosome-positive, significant splenomegaly. (2) chronic monocytic leukemia: white blood cell count light to moderate increased, liver, spleen, lymph nodes was not significant, blood and bone marrow to mature monocytes, occasionally immature monocytes.
    (3) lymphoma: painless enlargement of lymph nodes was progressive, deep lymph nodes may compress adjacent organs, blood, bone marrow smears and biopsy to find of Reed-sternbery cells or lymphoma cells. Lymph node biopsy shows: normal follicular structure of a large number of abnormal lymphocytes or tissue destruction; the capsule surrounding tissue Similarly abnormal lymphocytes or tissue cell infiltration; the the veins sinus also destruction.
    (4) lymph node tuberculosis limitations: often the neck lymph nodes, lymph node softer texture, tenderness and adhesions, and even necrosis or ulceration. Lymph node biopsy: Mycobacterium tuberculosis or caseous necrosis. Effective anti-TB treatment.
    (5) virus infection: lymphocytosis polyclonal, the increase is temporary, with the control of infection, lymphocyte count returned to normal.

    【Conventional treatment]
    CML clinical separable chronic phase, accelerated phase, blast phase three phases, the various stages of clinical manifestations vary, chronic phase treatment of Chinese medicine mainly with the chemotherapy drug treatment, accelerated phase and blast phase should be based chemotherapy, with Chinese medicine treatment.
    Western medicine treatment
    (A) chronic myeloid leukemia
    Efficacy criteria: determination of the effect of treatment of CML can be divided into ibid evaluation the blood morphological, cytogenetic, and molecular biology water. CML hematologic remission criteria: no clinical manifestations of anemia, bleeding, infection, and leukocyte infiltration; blood: red blood cells is higher than 100 g / L, white blood cell count less than 10 x 109 / L classification no immature cells, platelets (100 to 400) × 109 / L; normal bone marrow. Standard cytogenetic remission in CML ph1 chromosome disappeared flag CML clone.
    2, single chemotherapy drugs in the treatment of single-drug therapy for CML drug applications include alkylating agents such as: busulfan, melphalan, chlorambucil, dibromo-mannitol, etc., antimetabolites such as hydroxyurea, 6 – mercaptopurine (6 – A-level MP), 6 – sulfur birds drift methotrexate (6-TG), the homoharringtonine alkali as well as the Chinese Academy of Medical Sciences, Hematology Research and application of traditional Chinese medicine Indirubin and iso indigo.
    3, in combination with chemotherapy by combination chemotherapy in the treatment of acute leukemia monotherapy inspiration, try a combination chemotherapy treatment for CML people in recent years.
    4, interferon-interferon (IFN) has antiviral, inhibition of cell proliferation, inducing differentiation, and immune regulation, IFN α, β, γ can be divided into three categories of IFN-α and IFN-β on the acid-stable, with the same receptor by leukocytes and fibroblasts.
    5, bone marrow transplantation and peripheral blood stem cell transplantation
    (1) and autologous bone marrow transplantation (ABMT) or autologous peripheral blood stem cell transplantation (APBCT): the ABMT and APBSCT treatment of CML mainly to extend chronic or terminally ill patients returned to chronic phase, thus prolonging the survival of patients.
    (2) syngeneic bone marrow transplantation: such BMT BMT treatment of CML disease and the earliest attempt.
    (3) of allogeneic bone marrow transplants: allogeneic bone marrow transplantation (ALLo-BMT) is almost the only means to completely cure CML, is also the best method of treatment of CML.
    (4) the treatment of CML accelerated phase and blast phase enters the accelerated phase disease condition and more unstable, and about 2/3 of the patients and subsequent rapid change. This stage CML late, treatment is more difficult.

    【Prognosis and outcome]
    Currently less than 40 years of age, splenomegaly obvious peripheral blood platelet lower percentage of the original cell, CR is less than 1 year, and the BMT before time is short are CML favorable factors. CML eventually merged myelofibrosis, acute leukemia and multiple organ failure, concurrent infection, bleeding, and other serious complications and death. Slow gonorrhea process disparity varies as short as 1 to 2 years, as long as 5 to 10 years, or even 20 years. Duration of disease and the urgency of the disease, systemic symptoms, hepatosplenomegaly, blood and bone marrow changes. Generally older, the prognosis is good, the asymptomatic period before treatment, longer survival, and vice versa prognosis is poor, the common cause of death was infection, especially in the more common lung infection. Chronic CML and death in some rare cases.

    [Difficulties and Countermeasures]
    Chronic myeloid leukemia is a hematological malignancies the domestic take Integrative Medicine, indeed achieved some results, but difficult for some patients to avoid the recurrence of the rapid changes caused by multiple organ failure, infection, bleeding death. However, how to prolong the survival of patients of chronic leukemia, and prevention of chronic leukemia, CML is placed in front of us the difficulties.
    An emphasis on early detection and timely diagnosis, get treatment as soon as possible to obtain long-term survival on the basis of CML patients. By raising awareness of the disease, where the suspected CML signs should be promptly to the hospital for treatment, peripheral blood examination as a routine examination in general should be extensive, so that the blood test basic means of early detection of CML.
    In the chronic phase, should not take too radical treatments, such as combination chemotherapy, easy to procure acute change, should attract the attention of clinicians to avoid them; should always pay attention to changes in the condition of hair management in a timely manner in the chronic phase, take timely measures to prevention and treatment; Western medicine to be the retinoic acid induced differentiation medication may delay the occurrence of rapid change. Treatment in the chronic phase of the law of the traditional Chinese medicine the rousing and chief facilities the, Jieduhuoxue to Quxie righting Yiqiyangyin, change in remission maintenance therapy, further righting to clear its vestiges prevent repeated conducive stable disease; combined with interferon treatment when necessary, to obtain relief from the genetic point of view, is indeed beneficial to prolong survival; conditionally bone marrow transplantation in chronic phase line, there is hope to be long-term disease-free survival and even cure is possible, but the poison The side effects of bone marrow-derived difficult, expensive economic burden factors limit its wide range of applications, has its limitations.
    Rapid change occurs, should adopt the method of Integrative therapy, traditional Chinese medicine from the perspective of drug Yun blood stasis in Treating, due to drug Yun course of time, not of blood stasis, Yu flaming generalized Erzhi should understand its poison , of stasis, Quxie the treatment effect, ill win over Western medicine should be the right amount of chemotherapy and actively cooperate with supportive therapy treatment to sick to survive is appropriate.

    【Rehabilitation guidance]
    Life conditioning contact with radioactive substances and chemicals such as benzene, should strengthen labor protection, regularly check blood. The application may lead to leukemia drugs such as cytotoxic drugs, such as chloramphenicol should be careful. CML, CLL occurred in the elderly, slow onset. Longer course, the prognosis is poor, so to ensure early detection, early diagnosis and treatment. Once the disease and to maintain oral hygiene to prevent infection. To to do flirting Chi careful living, shelter from the wind cold. Actively participate in the exercise.
    2, diet conditioning
    (1) Jujube sheep soup with sheep tibia two crack 30, red dates, add clean boiled, seasoning served the. The party Spleen Qi, kidney and blood attack efficiency.
    (2) porridge yam Gorgon chemotherapy poor appetite should be chosen yam the Gorgon porridge served the spleen and stomach, promote absorption of food.
    (3) hemorrhagic fever Xianou 30g fresh Rhizoma Imperatae 30g Jiantang take can alleviate the symptoms.
    Psychotropic suffering from leukemia, to have a correct understanding of, and establish the ideas to overcome the disease, mood, reduce adverse stimulation and overworked, get more exercise, increased resistance to disease.

    Research Progress
    From cult poison of chronic leukemia chronic leukemia Zhengjia lump in the abdomen, sputum nuclear M. scrofulaceum its characteristic features are cult poison invading organism lurking meridian block air machine running, falling into stagnation gas blood with the gas line, the gas line is the blood line, qi stagnation and blood stasis, With the occurrence of qi stagnation and blood stasis, stasis accumulation of falling into a lump in the abdomen; qi stagnation body fluid transport and adverse condensate integrated sputum, hair M. scrofulaceum sputum nuclear. Righteousness deficiency is the the cult poison feelings of internal.
    2 phase fire frivolous reasons CML CML pathological hyperplasia excitement was undoubtedly the signs of bad yin yang. Kidney main bone marrow, so the disease is located in the kidney, the kidney yang the excitement – phase fire frivolous, which was mainly CML pathogenesis. Due the frivolous the phase hot defended Kulie, can large debilitating suffering really overcast, while Qi and Yin injury, lack of essence and blood, is the so-called “vitality of thieves, malignant proliferation of non-self-limiting chronic myeloid leukemia cells, disruption of normal hematopoietic function is relatively consistent. Without static phase fire moving, and cause intensified Yun heat into poison, harm the vitality of the results is relatively stable chronic phase is reduced to accelerated phase CML, is difficult to avoid the deterioration Zhiji change and eventually died. Therefore, the key is to slow the occurrence of the grain, the development of the body’s internal imbalance of yin and yang.

    Doctors Forum
    Ma Mingzong-fire trial because of disease, dialectical consensus candidate from the right from wrong, depends on staging severance medicine differentiation of CML are the main types of chronic leukemia, the incidence rate of leukemia in third place. Although there is no disease name in medicine, but certain syndromes, such as “consumptive", “mouth of the plot," Blood “," fever “and a phase CML clinical performance, but it is indeed difficult to generalize the CML the whole process of disease, but also does not reflect the real and the evolution of law. CML malignant cells Keqin clone in the bone marrow and hematopoietic tissue, abnormal proliferation, invasion and destruction of human hematopoietic tissue dysfunction caused by disease. CML treatment should by Bianzheng with disease combined, to grasp the essence and evolution of the disease in the dialectical and systemic treatment accurately, the handle 治标与治本 relationship, if necessary, when Chief stopgap like to relieve symptoms, to stabilize the patient’s condition. Differentiation of genetic Prescription focuses on the following aspects: the initial of the disease or even sub-clinical phase, the pathogenesis I spilled-fire tune of yin and yang, into the liver with in bitter cold Xiehuo and products based treatment. The chronic phase mainly Qiyinliangxu governance when Yiqiyangyin righting purging fire detoxification Quxie, enter the accelerated phase CML blastic tendency to BNI, cure with natural indigo, toads; Quxie tumor suppressor, in order to reverse the the disease potential medicinal flavescens, Angelica, Rehmanniae; disease to late occurrence of rapid change or myelofibrosis secondary infection, bleeding and other deadly complications, performance Genki big bad evil Hot hyperactivity or cooked hot joy or moving blood by to governance when the solid protection Genki Qingrejiedu, cooling blood to stop bleeding, the medicinal buffalo horn, gypsum and other.

    Success Stories
    The Lu Shi Teng Medical the case – Qiyinliangxu, toxic heat flaming CML
    [Medical Record No.: 970 816 women, 50 negative, farmers, married. On April 2, 1997, outpatient visits.
    [Complained of]: fatigue, weight loss two years, found a lump in the left upper abdomen for about five months.
    History of present illness: nearly two years to feel frail fatigue, reduce food satisfied, progressive weight loss. Fullness after eating in the past five months since discovered lumps in the left upper abdomen, like the size of a fist, growing up, not pain. When afternoon mild chills, fever. Night sweats. Constipation. Urine without change. The past 10 days, mild cough, cough, a small amount of mucus white sputum. Happened 2 times in a year ago, epistaxis, no other history of bleeding.
    Past medical history: previously healthy, no special medical history.
    [Examination]: a temperature of 38.5 ° C, respiratory rate 24 breaths / min, pulse 100 beats / min, blood pressure 120/80mmHg.
    [Routine blood tests: hemoglobin 54g / L, erythrocyte 2 × 1012 / L, white blood cells 436 × 109 / L, platelets 530 × 109 / L.
    [Classification]: the myeloblast 3% promyelocytic 7% in promyelocytic 30% late promyelocytic 21%.
    [Routine urine examination was negative.
    [Chest] two lung markings, the shadow of the small piece of the right lower lung.
    Of a hospital for examination, “5177″ report: bone marrow smears showing hyperplasia hyperactive the grain system hyperplasia hyperactivity, each stage significantly increase, mainly in the late promyelocytic basophils significantly increase significantly inhibited red system megakaryocytes decreased platelet distribution does not reduce.
    The blood films leukocyte distribution is extremely increased, mainly for grain system, stages, mainly in the late promyelocytic platelet stacks.
    [Diagnosis] chronic myeloid leukemia.
    [Dialectical] Qiyinliangxu, toxic heat flaming
    [Governing Law] qi Yin qingrejiedu, and
    [Recipe] Kang the Blood Ning V + the Kang the Blood Ning adjuvant III (subtraction broom VII, Selaginella, Redstone ear, astragalus, dandelion, etc.) April 20, constipation disappeared, tongue, thin white fur. May 30, serving 28 above, the original symptoms, the spleen left rib under 5cm. Peripheral blood leukocytes 20 × 1012 / L, late promyelocytic 6%. In the course of treatment, without any toxicity.
    Review: based on clinical symptoms, blood films and bone marrow chip testing, although the lack of ph check, but this cases of chronic myeloid leukemia diagnosis can be established. Right lower lung rales may be caused by infection, may also be due to the leukemia cells due to the infiltration of the lung tissue, generally leukemia immature cells in 100 × 1012 / L or more, may produce lung tissue infiltration.

    [Experience in】
    Chinese medicine treatment of chronic leukemia differentiation with disease was still with the basic principles of Integrative Medicine to treat chronic leukemia can really improve the efficacy and prolong survival. Walking in Western medicine combined road is based on the basic theory of Chinese medicine is based, give full play to the strengths of the diagnosis and treatment based on the overall emphasis on the local part and the whole combination, both noted that the specimens of urgency, but also pay close attention to changes in condition, according to the Leukemia different stages different syndromes, the different manifestations flexible diagnosis and treatment. Early in the disease in remission, blastic phase, evil and righteousness is not imaginary, attack evil, diagnosis and treatment of prescription, the election day prostrata, the bulbifera hair seven, diffusa, tonkinensis and, so on to detoxification Quxie; contend diseases medium-term in pathogen qi gradually imaginary evil yet implemented governance subtraction differentiation to supplementation and attack to to impose Yiqiyangyin, Qingrejiedu conquer optional Kang Shengxuening to join the Taibai flowers, Leontice, Radix, honeysuckle, forsythia, diffusa qingrejiedu, join Taibai Ginseng, taibai meters, astragalus, day six winter, medlar, etc. Yiqiyangyin; advanced disease, chemotherapy the late Qiyinliangxu evil Sheng, or a systemic failure stage tonic, Chief Qingrejiedu be Shenqi kill of white soup subtraction therapy (Taibai ginseng, astragalus, Ophiopogon, Polygonatum, Angelica, Pueraria etc. Smell composition). During chemotherapy, patients often accompanied by nausea, vomiting, eating less, poor appetite, body tired fatigue performance timely together Erchen flavored differentiation give Shengmaisan, to Yiqiyangyin, spleen and stomach, Jiangni vomiting, alleviate gastrointestinal side effects of chemotherapy brought about the smooth progress of chemotherapy.