Keywords: bone marrow transplant leukemia
The bone marrow transplant is a medical technology gradually developed from the 1950s. Bone marrow transplantation is refers to the transplantation of bone marrow cells from a human body (generally via intravenous input) from one person to another body. Rather, the “bone marrow transplantation" should be called “hematopoietic stem cell transplantation.
Hematopoietic stem cells are the “seed" of all blood cells in the human body, red blood cells, white blood cells (including granulocytes, monocytes, lymphocytes) and platelets by it after several differentiation and development from. Hematopoietic stem cell self-replication (hematopoietic stem cells that generate new), to replenish itself.
Hematopoietic stem cell transplantation
The first step for leukemia patients to large doses of chemotherapy and radiotherapy. Main purposes:
1 maximize kill the leukemia cells of the patient’s body;
2 wholesale destruction of normal hematopoiesis and immune function of the patient’s body, the immune cells can not attack the implantation of allogeneic cells, providing living space for the newly implanted cells.
The second step will be the normal human hematopoietic stem cells donated enter the leukemia patients, to let leukemia patients restore hematopoiesis and immune function to achieve the purpose of cure disease.
1970s, bone marrow transplantation is gradually mature, many leukemia, certain malignant tumors and blood of patients who have been treated, about 5O% to 70% of acute and chronic leukemia patients with long-term survival. Make an important contribution to the development of this technology, the American physician Thomas (ED Thomas) 1990 year Nobel Prize in Medicine.