Keywords: chronic superficial gastritis
Chronic superficial gastritis is no specific drug treatment, general advocate asymptomatic Needless therapy, with symptoms can give rational drug use based on the etiology, pathology and clinical symptoms. Specific treatment method are as follows:
(1) cause of treatment: the best way to eliminate the causative factors for the treatment and prevention of chronic superficial gastritis. It should avoid stress, quit smoking, limit alcohol consumption amount, try not to take drugs to stimulate the stomach, aggressive treatment of chronic tonsillitis, sinusitis, dental caries and throat infection focus.
(2) diet: chronic superficial gastritis patient diet should be light, regular, regular meals, to avoid excessive acid is too hot, cold and rough food.
(3) drug treatment: drug treatment of chronic superficial gastritis can be roughly divided into two categories: drugs to protect the gastric mucosa and the elimination of the drug to the detriment of the gastric mucosa factors.
Drugs to protect the gastric mucosa: ① Health carbenoxolone: succinic acid half ester is made of licorice after acid hydrolysis, can enhance gastric mucus secretion, prolong life and mild suppression of gastric epithelial cells to the vitality of pepsin, it can protect the stomach mucosa from bile injury, avoid H + counter-proliferation. Usage 100mg, three times, two weeks after the date changed to 50mg, day three times, half an hour before a meal served 4-5 weeks for a course. The side effects Shuinazhuliu, it should at the same time taking hydrochlorothiazide and potassium. ② sucralfate: the drug with pepsin complexation inhibit the enzyme to break down proteins, and network and gastric mucosal protein synthesis protective film to prevent gastric acid, pepsin and bile acid infiltration and erosion. In addition, the drug is able to promote the metabolism of the gastric mucosal cells. Usage: 1.0g, 3 to 4 times a day. Particles ③ Marzulene-S: the drug containing a water-soluble B334 and L-glutamine. Water-soluble B334 direct role in the gastric mucosa, the local inflammation disappeared. L-glutamine and gastrointestinal mucosal epithelial component of glycosaminoglycans and glucosamine together, involved in promoting tissue repair in order to achieve therapeutic purposes. Usage: 670mg, 3 times a day. ④ gastritis dry syrup: drug gentamicin sulfate, hydrochloric acid, procaine, VitB12 etc. composition. Has anti-inflammatory, analgesic, and promote the role of gastric mucosal repair. Usage: 5g, 3 times a day. ⑤ Smecta: the drug of bacteria and viruses has a strong fixed capacity, has strong coverage of the digestive tract mucosa. And the role of the mucus can improve the toughness of the gastrointestinal mucosa glial against various attacks factor. Usage: 3g, 3 times a day. ⑥ Others: Weimeisu 2 to 4, 3 times a day orally; stomach membrane prime 2 ~~ 3g, 3 times a day orally; aluminum hydroxide gel, 10mg, 3 times a day orally; to cover stomach flat four, three times a day orally; prostaglandin E250 ~ 150mg, 3 times a day orally. Can play a role to protect and improve the gastric mucosa.
Drugs to eliminate the factors of gastric mucosal damage: (1) control: HP and chronic gastritis, especially chronic active gastritis and is closely related to kill the HP the drug is beneficial in the treatment of chronic superficial gastritis, HP infection in vitro tests HP to penicillin, aminoglycosides, tetracyclines, cephalosporins, macrolides, nitroimidazoles, furans, and bismuth sensitive. It is clinically often used the following drugs: tripotassium bismuth citrate salt (TDB) 120mg, 4 times a day, for a course in four weeks; amoxicillin 1.5g, 2 times a day, and even served eight days instead of 1.0g 2 times a day, and even served 28 days; furazolidone 0.1g, 3 times a day the continuous take 2 to 4 weeks; metronidazole 0.4g, 3 times a day orally for 14 days for a course; Rebekah orally every times 80mg, 2 times a day, even for 3 to 4 weeks for a course;, etc. In addition, you can also strengthen through joint medication clear HP’s effect. ② gastric parietal cell receptor antagonists: the histamine H2 receptor, the gastrin receptor and acetylcholine receptor antagonist for the treatment of gastritis, particularly suitable for especially high acid, can reduce gastric acid secretion. Commonly used in clinical cimetidine, ranitidine, famotidine; proglumide, atropine, propantheline Sim can also be used for this disease. Piperazine of topiramate nitrogen level can selectively inhibit gastric acid secretion and heart rate, pupil, prostaglandins and gastric peristalsis had no significant effect. Usage: 50mg, 2 times a day. Losec for H +-K +-ATP enzyme blockers also inhibit gastric acid secretion. ③ control and improve bile reflux drugs: pyloric function disorders, bile reflux damage the gastric mucosal barrier caused by gastritis, it can be used metoclopramide, vomiting Spirit, domperidone, cisapride, cholestyramine treatment, such The drugs have to promote gastric emptying, prevent reflux role. Specific usage: metoclopramide 10mg, day 3 times; the antiemetic Spirit 50 to 100mg three times a day; Motilium 10 ~~ 20mg, day 3 to 4 times; cisapride 5 ~ 10mg, day 2-3 times; elimination cholestyramine 3 ~ 4g, 4 times a day. (4) anti-pepsin drugs: vulcanized polysaccharide with pepsin leaving the inactivated to avoid gastric mucosal damage, commonly used by sucralfate, chondroitin sulfate.