Keywords: Gastric etiology and pathogenesis
A drug multiple drugs Non-steroidal anti-inflammatory drugs such as aspirin, indomethacin, phenylbutazone, as well as adrenal corticosteroids. Was a non-ionic and relatively fat-soluble aspirin in the acidic environment can destroy lipoprotein layer of the gastric epithelial cells, weakened mucosal barrier caused by hydrogen ions reverse osmosis to the mucosa, causing inflammation exudate, edema, erosion, bleeding or shallow ulcers. Adrenal corticosteroids can cause the steroid ulcer or perforation, with gastric acid and pepsin secretion, reduce the secretion of gastric mucus, weakened mucosal barrier, inhibiting gastric epithelial cell regeneration. Other drug such as snakeroot preparation, digitalis, antibiotics, potassium, such as caffeine can also cause the disease.
, Alcoholism is also a common cause of the disease. Large number of alcohol induced acute gastric erosion and bleeding. Ethanol soluble the gastric epithelial lipoprotein layer, or ethanol after cervical mucus cells of the blood flow damages glands, reduced gastric mucus, which can cause gastric mucosal barrier damage, lead to hydrogen ions reverse osmosis cause inflammation oozing, bleeding, ulcers, collectively referred to as stress ulcer. ACTH, adrenal cortex hormone released in large quantities in the case of stress, a significant increase in gastric secretion, reduced gastric mucus, mucus cells reduced DNA synthesis, on the other hand by the autonomic mucosal vasospasm, combined with hypovolemia gastric mucosal blood flow reduction , hypoxia, energy metabolism is affected, lesions at the mast cells to release histamine and 5 – serotonin and other active substances, so that local vasodilation, exudation, edema, and further excited parietal cell H2 receptor acid secretion, leading to the stomach mucosal erosion, the formation of ulcers.